CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 68 enrolled
Drug / intervention
Bortezomib +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00378105
NCT00378105Phase 2Active

An Open-Label Phase I/II Study of the Safety and Efficacy of Bortezomib, Lenalidomide and Dexamethasone Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma

Dana-Farber Cancer Institute·interventional·Posted Sep 19, 2006·Updated Feb 24, 2026

In Brief

A Phase 2 clinical trial evaluating Bortezomib, Lenalidomide, and 1 other intervention for Multiple Myeloma. Active but no longer recruiting, targeting 68 participants across 3 sites.

Detailed Summary

The purpose of this study is to determine the safety and efficacy of the bortezomib, lenalidomide and dexamethasone combination in patients with newly diagnosed multiple myeloma. We are looking for the highest dose of the combination that can be given safely and see how well it works as a combination in newly diagnosed patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2Active
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 19, 2006
Enrollment StartSep 1, 2006
Primary CompletionJul 1, 2009
Study CompletionDec 1, 2026
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 19.8 years ago

Interventions

Bortezomibdrug

Intravenously on days 1, 4, 8 and 11 of a 21 day cycle for a minimum of 8 cycles (dosage will vary depending upon when the participant enters the trial)

Lenalidomidedrug

Taken orally twice a day for 2 weeks (days 1-14) of each 21-day cycle for a minimum of 8 cycles (dosage will vary depending upon when participant enters trial).

dexamethasonedrug

Taken orally on days 1,2,4,5,8,9,11 of a 21-day cycle for a minimum of 8 cycles.