CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 588 enrolled
Drug / intervention
Insulin Glulisine +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00384085
NCT00384085Phase 4Completed

All to Target Trial Lantus® (Insulin Glargine) With Stepwise Addition of APIDRA® (Insulin Glulisine) or Lantus With One Injection of Apidra vs a Twice-Daily Premixed Insulin Regimen (Novolog® Mix 70/30) in Adult Subjects With Type 2 Diabetes Failing Dual or Triple Therapy With Oral Agents: a 64-week, Multi-center, Randomized, Parallel, Open-label Clinical Study.

Sanofi·interventional·Posted Oct 4, 2006·Updated May 6, 2011

In Brief

A Phase 4 clinical trial evaluating Insulin Glulisine, Insulin Glargine, and 1 other intervention for Diabetes Mellitus, Type 2. Completed, enrolled 588 participants across 1 site.

Detailed Summary

The primary objectives were: * To demonstrate the superiority of Lantus plus stepwise addition of mealtime Apidra® (Lantus/Apidra-3) versus twice-daily Premixed insulin based on the proportion of patients achieving target glycemic control (as measured by hemoglobin A1c \[HbA1c\] \<7.0%) at Week 60 * To demonstrate the noninferiority of Lantus plus addition of 1 mealtime Apidra injection (Lantus/Apidra-1) versus twice-daily Premixed insulin based on the reduction from Baseline to Week 60 in HbA1c

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 4, 2006
Enrollment StartMay 1, 2006
Primary CompletionMar 1, 2010
TodayJul 2, 2026
Enrollment to primary: 3.8 yearsPosted 19.7 years ago

Interventions

Insulin Glulisinedrug

Subcutaneous injection up to 1 injection per day

Insulin Glarginedrug

Subcutaneous injection once-a-day

Premixed Insulindrug

Subcutaneous injection twice-a-day.

Insulin Glulisinedrug

Subcutaneous injection up to 3 injections per day.