At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 20 enrolled
Drug / intervention
Nicotine +1 moredrug
Likely dose
Nicotine 3mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Nicotine on Pain After Third Molar Extraction.
In Brief
A Phase 4 clinical trial evaluating Nicotine and Placebo for Dental Crowding. Completed, enrolled 20 participants across 1 site.
Detailed Summary
Third molar surgery is complicated by pain and swelling for several days after surgery. Non-steroidal antiinflammatory drugs have been useful in combination with opioids for treatment. Nicotine has antiinflammatory and pain relieving properties. We will use nicotine or placebo as a nasal spray before surgery to determine whether nicotine affects pain or inflammation.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDental Crowding
CountriesUnited States
Collaborators--
Timeline
Phase 4CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartJul 2004
First PostedOct 2006
Primary CompletionMay 2009
Study CompletionJun 2009
TodayJul 2026
First PostedOct 9, 2006
Enrollment StartJul 1, 2004
Primary CompletionMay 1, 2009
Study CompletionJun 1, 2009
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 19.7 years ago
Interventions
Nicotinedrug
Nicotine nasal spray 3mg x 1 before surgery
Placeboother
Placebo nasal spray 0mg x 1 before surgery