At a glance
ClinicalIndex Comparison Record- ✓Symptomatic congestive heart failure, NYHA Class II to IV
- ✓Ejection fraction <40% documented within 6 months
- ✓Stable on conventional therapy (digoxin, diuretics, ACE inhibitors, hydralazine, nitrates, ARBs, beta blockers) with no dosage changes for ≥4 weeks
- ✕Active alcohol or illicit drug use
- ✕Myocardial infarction or unstable angina within 3 months
- ✕Obstructive valvular disease
- ✕Exercise-induced sustained arrhythmias or symptomatic myocardial ischemia
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Chronic Changes in Heart Rate on Congestive Heart Failure
In Brief
A clinical study evaluating heart rate setting for Heart Failure, Congestive. Completed, enrolled 13 participants across 1 site.
Detailed Summary
This will be a double blind randomized crossover study of patients with congestive heart failure and a heart rate dependent upon a permanent pacemaker. Thus, at all times the heart rate can be maintained at a set rate by adjusting the settings of the pacemaker. Acute and chronic effects of heart rates of 60, 75, and 90 beats per minute will be evaluated. The effect of heart rate will be determined by measuring ejection fraction by nuclear ventriculography, six minute walk distance, and peak oxygen consumption on a maximal exercise test.