CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 23 enrolled
Drug / intervention
Carcinoembryonic Antigen-Expressing Measles Virus +2 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00390299
NCT00390299Phase 1Completed
CompareCT.gov

Phase I Trial of a Measles Virus Derivative Producing CEA (MV-CEA) in Patients With Recurrent Glioblastoma Multiforme (GBM)

Mayo Clinic·interventional·Posted Oct 19, 2006·Updated Jan 2, 2020

In Brief

A Phase 1 clinical trial evaluating Carcinoembryonic Antigen-Expressing Measles Virus, Laboratory Biomarker Analysis, and 1 other intervention for Anaplastic Astrocytoma and 3 related conditions. Completed, enrolled 23 participants across 1 site.

Detailed Summary

This phase I trial studies the side effects and best dose of carcinoembryonic antigen-expressing measles virus (MV-CEA) in treating patients with glioblastoma multiforme that has come back. A virus, called MV-CEA, which has been changed in a certain way, may be able to kill tumor cells without damaging normal cells.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnaplastic Astrocytoma, Anaplastic Oligodendroglioma, Mixed Glioma, Recurrent Glioblastoma
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 1CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 19, 2006
Enrollment StartOct 23, 2006
Primary CompletionNov 29, 2018
Study CompletionNov 30, 2019
TodayJul 2, 2026
Enrollment to primary: 12.1 yearsPosted 19.7 years ago

Interventions

Carcinoembryonic Antigen-Expressing Measles Virusbiological

Given via injection into resection cavity or around tumor bed and/or IT

Laboratory Biomarker Analysisother

Correlative studies

Therapeutic Conventional Surgeryprocedure

Undergo en bloc resection