At a glance
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Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children
In Brief
An observational study evaluating Remove Mn from PN if evidence of increased brain Mn on MRI for Parenteral Nutrition and 3 related conditions. Completed, enrolled 122 participants across 1 site.
Detailed Summary
Manganese (Mn) is an essential metal required for normal growth and development. However, exposure to high Mn levels can be toxic to the brain. The objectives of this project are to identify neonatal and young pediatric populations that are at increased risk of excessive brain Mn deposition and altered cognitive and motor development based on their dietary parenteral Mn exposure, and to make sound and evidence-based recommendations for appropriate Mn supplementation and monitoring of infants and young children receiving parenteral nutrition (PN). Our studies are designed to test the hypotheses that, compared with unexposed age-matched controls, infants and young children receiving prolonged Mn-supplemented PN will have increased deposition of Mn in their brains and lower scores on neurodevelopmental, cognitive and psychophysiological assessments.
Study Details
Timeline
Interventions
Withhold Mn-containing trace element cocktail and add zinc, copper and chromium individually to PN