At a glance
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Brain Manganese Deposition in High Risk Neonates
In Brief
An observational study evaluating remove Mn from PN if evidence of increased brain Mn on MRI for Necrotizing Enterocolitis and 2 related conditions. Completed, enrolled 43 participants across 1 site.
Detailed Summary
Excessive exposure to manganese (Mn) results in Mn deposition in the brain causing adverse neurological effects. Sick infants requiring parenteral nutrition (PN) may be at increased risk of Mn neurotoxicity because neonatal PN solutions contain high concentrations of Mn. This proposal will investigate brain deposition of Mn, a paramagnetic element, by magnetic resonance (MR) imaging in preterm and term neonates receiving Mn-supplemented PN and gestational age-matched control infants. The goals of this project are to identify neonatal populations that are at increased risk of excessive brain Mn deposition based on their gestational age, iron status, hepatic function and dietary Mn intake, and to make evidence-based recommendations for appropriate Mn supplementation and monitoring of infants receiving PN.
Study Details
Timeline
Interventions
trace element cocktail will be withheld and zinc, copper and chromium added to PN individually.