CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 51 enrolled
Drug / intervention
ocriplasmin +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00412451
NCT00412451Phase 2Completed

A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of DME.

ThromboGenics·interventional·Posted Dec 18, 2006·Updated Dec 17, 2014

In Brief

A Phase 2 clinical trial evaluating ocriplasmin and Sham injection for Diabetic Macular Edema. Completed, enrolled 51 participants across 15 sites in 6 countries.

Detailed Summary

A multicenter study to compare multiple doses of intravitreal microplasmin for non-surgical PVD induction for treatment of patients with DME.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, Germany, Italy, Netherlands, Spain, United Kingdom
Collaborators--

Timeline

Phase 2CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedDec 18, 2006
Enrollment StartDec 1, 2006
Primary CompletionJan 1, 2010
Study CompletionMar 1, 2010
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 19.5 years ago

Interventions

ocriplasmindrug

Intravitreal injection, single administration

Sham injectionother

Sham intravitreal injection