At a glance
ClinicalIndex Comparison RecordN/ACompleted· 238 enrolled
Drug / intervention
Caloric Restriction (CR) +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE)
In Brief
A clinical study evaluating Caloric Restriction (CR) and Control for Aging. Completed, enrolled 238 participants across 3 sites.
Detailed Summary
The purpose of this study is to test the hypothesis that two years of sustained 25% caloric restriction (CR) in men age 21-50 (inclusive) and women age 21-47 (inclusive) will slow aging and protect against age-related disease processes.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAging
CountriesUnited States
Collaborators--
Timeline
N/ACompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJan 2007
Enrollment StartMay 2007
Primary CompletionNov 2012
TodayJul 2026
First PostedJan 26, 2007
Enrollment StartMay 1, 2007
Primary CompletionNov 1, 2012
TodayJul 2, 2026
Enrollment to primary: 5.5 yearsPosted 19.4 years ago
Interventions
Caloric Restriction (CR)behavioral
Participants follow a diet with 25% fewer calories than calculated at baseline over a period of 24 months
Controlbehavioral
Participants continue their current diet for 24 months