CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 7,112 enrolled
Drug / intervention
Nitrous Oxide +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00430989
NCT00430989Phase 4Completed
CompareCT.gov

Large, Randomised, Parallel-group, Controlled Trial, With Patients Randomly Allocated to Either N2O-containing (70% N2O in Oxygen [FiO2 0.3]) or N2O-free (70% Nitrogen in Oxygen [FiO2 0.3]).

Bayside Health·interventional·Posted Feb 2, 2007·Updated Jan 20, 2026

In Brief

A Phase 4 clinical trial evaluating Nitrous Oxide and No Nitrous Oxide for Coronary Artery Disease. Completed, enrolled 7,112 participants across 1 site.

Detailed Summary

To investigate the safety of nitrous oxide (N2O) anaesthesia in patients with risk factors for coronary artery disease undergoing major surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoronary Artery Disease
CountriesAustralia
CollaboratorsNational Health and Medical Research Council, Australia

Timeline

Phase 4CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 2, 2007
Enrollment StartApr 1, 2007
Primary CompletionSep 1, 2013
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 19.4 years ago

Interventions

Nitrous Oxideother

General anaesthesia with the inclusion of Nitrous Oxide at 70%

No Nitrous Oxideother

General anaesthesia with no use of Nitrous Oxide