CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 60 enrolled
Drug / intervention
ocriplasmin +2 moredrug
Likely dose
ocriplasmin 75µgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00435539
NCT00435539Phase 2Completed

A Randomized, Sham-Injection Controlled, Double-Masked, Ascending-Dose, Dose-Range-Finding Trial of Microplasmin Intravitreal Injection for Non-Surgical Posterior Vitreous Detachment (PVD) Induction for Treatment of Vitreomacular Traction (VMT).

ThromboGenics·interventional·Posted Feb 15, 2007·Updated Dec 17, 2014

In Brief

A Phase 2 clinical trial evaluating ocriplasmin and Sham Comparator for Vitreomacular Traction. Completed, enrolled 60 participants across 4 sites in 2 countries.

Detailed Summary

A multicenter study to compare multiple doses of intravitreal microplasmin for non-surgical PVD induction for treatment of patients with vitreomacular traction.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, Germany
Collaborators--

Timeline

Phase 2CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 15, 2007
Enrollment StartFeb 1, 2007
Primary CompletionJan 1, 2009
Study CompletionFeb 1, 2009
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 19.4 years ago

Interventions

ocriplasmindrug

Intravitreal injection of ocriplasmin solution containing 75µg of ocriplasmin.

ocriplasmindrug

Intravitreal injection of ocriplasmin solution containing 125µg of ocriplasmin with up to 2 additional (open label) 125µg ocriplasmin injection at 1 month interval.

Sham Comparatordrug

Intravitreal sham injection