At a glance
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Study of Interaction Between Adipose and Muscle Tissues in the Control of Muscle Mitochondrial Functions
In Brief
An observational study for Mitochondrial Respiratory Chain Deficiencies. Completed, enrolled 60 participants across 1 site.
Detailed Summary
Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance. In skeletal muscle, insulin resistance has been correlated with reduced mitochondrial oxidative functions. According to the actual theory, mitochondrial dysfunctions are proposed to play a causal role in the aetiology of insulin resistance. Mechanisms involve increased intramyocellular lipids storage. Yet, the causes responsible for the decline in muscle mitochondrial functions remain to be elucidated. The investigators hypothesize that these alterations are induced by combined changes in plasma profiles of lipids and adipokines, which originate from perivisceral adipose tissue. The study aims at answering the following questions : * Are muscle mitochondrial functions altered in association with increased perivisceral adipose tissue storage? * Do changes in the pattern of plasma lipids and adipokines explain this correlation?