At a glance
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Longitudinal Study of Primary Ciliary Dyskinesia: Participants 5-18 Years of Age
In Brief
An observational study for Primary Ciliary Dyskinesia. Completed, enrolled 150 participants across 5 sites in 2 countries.
Detailed Summary
Mucociliary clearance, in which mucus secretions are cleared from the breathing airways, is the primary defense mechanism for the lungs. Inhaled particles, including microbes that can cause infections, are normally entrapped in mucus on the airway surfaces and then cleared out by the coordinated action of tiny hair-like structures called cilia. Individuals with primary ciliary dyskinesia (PCD) have defective mucociliary clearance, which in turn leads to lung infections and disease. The purpose of this study is to determine how lung disease progresses over time in children and adolescents with PCD.