CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 357 enrolled
Drug / intervention
Chloroquine +1 moredrug
Likely dose
Chloroquine 80 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00455403
NCT00455403N/ACompleted
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Genotoxic Stress, Atherosclerosis, and Metabolic Syndrome- Aim 3

Washington University School of Medicine·interventional·Posted Apr 3, 2007·Updated Dec 15, 2021

In Brief

A clinical study evaluating Chloroquine and Placebo Comparator for Metabolic Syndrome X and 4 related conditions. Completed, enrolled 357 participants across 1 site.

Detailed Summary

Metabolic syndrome consists of a group of co-occuring conditions that increase an individual's risk of developing heart disease, stroke, and diabetes. The purpose of this study is to evaluate the long-term effectiveness of chloroquine, a protein-activation medication, at reducing the progression of atherosclerosis in patients with the metabolic syndrome. Sub-study: Vascular endothelial growth factor(VEGF)and Cardiometabolic Risk, The purpose is to determine if the association of VEGF with atherosclerosis indicates that it should be a marker of the disorder.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMetabolic Syndrome X, Overweight, Hypertension, Dyslipidemias, Prediabetic State
CountriesUnited States
CollaboratorsNational Heart, Lung, and Blood Institute (NHLBI), Singulex

Timeline

N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedApr 3, 2007
Enrollment StartApr 1, 2006
Primary CompletionDec 1, 2009
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 19.2 years ago

Interventions

Chloroquinedrug

One tablet of 80 mg of chloroquine on a daily basis for 12 months followed by 12 months off drug with 1 visit at month 24

Placebo Comparatordrug

Chloroquine Placebo tablet daily for 12 months followed by 12 months off drug with 1 visit at month 24