CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 25 enrolled
Drug / intervention
Carvedilol CR + Lisinopril +1 moredrug
Likely dose
Carvedilol CR + Lisinopril 20 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00459056
NCT00459056Phase 3Completed
CompareCT.gov

The Vascular Effects of Carvedilol Controlle Release (CR) + Lisinopril Versus Lisinopril + Hydrochlorothiazide (HCTZ) in Abdominally Obese Hypertensive Patients

St. Paul Heart Clinic·interventional·Posted Apr 11, 2007·Updated Dec 6, 2013

In Brief

A Phase 3 clinical trial evaluating Carvedilol CR + Lisinopril and Lisinopril + HCTZ for Abdominal Obesity and Hypertension. Completed, enrolled 25 participants across 1 site.

Detailed Summary

The purpose of this study is to compare the effects of two different combination therapies for high blood pressure on vascular health.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAbdominal Obesity, Hypertension
CountriesUnited States
CollaboratorsGlaxoSmithKline

Timeline

Phase 3CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedApr 11, 2007
Enrollment StartApr 1, 2007
Primary CompletionMay 1, 2010
TodayJul 2, 2026
Enrollment to primary: 3.1 yearsPosted 19.2 years ago

Interventions

Carvedilol CR + Lisinoprildrug

Participants were given Carvedilol CR + Lisinopril for three months. Oral medication. Carvedilol CR and Lisinopril combination therapy was initiated at 20 mg and 10 mg, respectively. Patients returned one week later and doses of carvedilol CR and lisinopril were increased to 40 mg and 20 mg, respectively, depending on blood pressure.

Lisinopril + HCTZdrug

Participants were given Lisinopril + HCTZ for three months. Oral medication. Lisinopril + HCTZ combination therapy was initiated at 12.5 mg and 10 mg, respectively. Patients returned 1 week later and doses of hydrochlorothiazide and lisinopril were increased to 25 mg and 20 mg, respectively, depending on blood pressure levels.