CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 30 enrolled
Drug / intervention
RSI sedation with etomidate/succinylcholine +1 moredrug
Likely dose
RSI sedation with etomidate/succinylcholine 0.3 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00462644
NCT00462644N/ACompleted
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A Single Dose of Etomidate During Rapid Sequence Induction in Trauma Patients Causes Significant Adrenocortical Insufficiency: A Prospective Randomized Study

University of Tennessee·interventional·Posted Apr 19, 2007·Updated Feb 23, 2010

In Brief

A clinical study evaluating RSI sedation with etomidate/succinylcholine and RSI sedation with fentanyl/midazolam/succinylcholine for Adrenal Insufficiency. Completed, enrolled 30 participants across 1 site.

Detailed Summary

Trauma patients are at increased risk for adrenal function insufficiency. A commonly used agent for rapid sequence intubation (RSI) is known to decrease adrenal function. We want to determine the incidence of adrenocortical insufficiency and its significance during the first 24 hours of resuscitation following RSI in trauma patients.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAdrenal Insufficiency
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedApr 19, 2007
Enrollment StartFeb 1, 2006
Primary CompletionAug 1, 2006
Study CompletionSep 1, 2006
TodayJul 2, 2026
Enrollment to primary: 6 monthsPosted 19.2 years ago

Interventions

RSI sedation with etomidate/succinylcholinedrug

etomidate 0.3 mg/kg IV plus succinylcholine 1 mg/kg IV

RSI sedation with fentanyl/midazolam/succinylcholinedrug

100 micrograms fentanyl IV, plus 5 mg midazolam IV, plus 1 mg/kg succinylcholine IV