CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 5 enrolled
Drug / intervention
sorafenib tosylate +8 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00466752
NCT00466752Phase 2Completed
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A Phase II Study of Sorafenib (Nexavar®) Prior to Radical Prostatectomy in Patients With High-Risk Localized Prostate Cancer

University of Washington·interventional·Posted Apr 27, 2007·Updated Nov 22, 2017

In Brief

A Phase 2 clinical trial evaluating sorafenib tosylate, microarray analysis, and 7 other interventions for Adenocarcinoma of the Prostate and 2 related conditions. Completed, enrolled 5 participants across 1 site.

Detailed Summary

This phase II trial is studying sorafenib tosylate and gene expression in patients undergoing surgery for high-risk localized prostate cancer. Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Studying samples of blood and tumor tissues in the laboratory from patients with prostate cancer may help doctors learn more about changes that occur in DNA after treatment with sorafenib tosylate

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAdenocarcinoma of the Prostate, Stage II Prostate Cancer, Stage III Prostate Cancer
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 2CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedApr 27, 2007
Enrollment StartDec 1, 2006
Primary CompletionApr 1, 2010
Study CompletionJul 1, 2011
TodayJul 2, 2026
Enrollment to primary: 3.3 yearsPosted 19.2 years ago

Interventions

sorafenib tosylatedrug

Given PO

microarray analysisgenetic

Correlative studies

immunohistochemistry staining methodother

Correlative studies

gene expression analysisgenetic

Correlative studies

needle biopsyprocedure

Correlative studies

therapeutic conventional surgeryprocedure

Undergo prostatectomy

laboratory biomarker analysisother

Correlative studies

western blottinggenetic

Correlative studies

RNA analysisgenetic

Correlative studies