At a glance
ClinicalIndex Comparison RecordN/ACompleted· 100 enrolled
Drug / intervention
Alteplase +1 moredrug
Likely dose
Alteplase 25 Mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Response to Instillation of Activase in the Pleural Cavity vs Placebo in the Management of Complicated Pleural Effusion/Empyema
In Brief
A clinical study evaluating Alteplase and Placebo for Pleural Effusion Associated With Pulmonary Infection and Bacterial Pleural Effusion Other Than Tuberculosis. Completed, enrolled 100 participants across 1 site.
Detailed Summary
The purpose of this study is to document the efficacy and safety of intrapleural instillation of Activase vs Placebo in the management of complicated pleural effusions and empyemas
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis
CountriesUnited States
CollaboratorsGenentech, Inc.
Timeline
N/ACompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartApr 2004
First PostedMay 2007
Primary CompletionOct 2008
Study CompletionAug 2009
TodayJul 2026
First PostedMay 2, 2007
Enrollment StartApr 1, 2004
Primary CompletionOct 1, 2008
Study CompletionAug 1, 2009
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 19.2 years ago
Interventions
Alteplasedrug
25 Mg of Alteplase in 100 cc of normal saline was instilled intrapeurally for daily for three days
Placebodrug
Placebo in 100 cc of normal saline was instilled intrapleurally daily for three days