At a glance
ClinicalIndex Comparison RecordN/ACompleted· 1,102 enrolled
Drug / intervention
Antibiotic PEP +1 moredrug
Likely dose
Antibiotic PEP 1000mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Open-Label Non-Inferiority Study to Examine the Impact of Pertussis Vaccination of Healthcare Workers on Post-exposure Prophylaxis
In Brief
A clinical study evaluating Antibiotic PEP for Pertussis. Completed, enrolled 1,102 participants across 1 site.
Detailed Summary
The purpose of this study is to compare the effectiveness of two strategies of post-exposure prophylaxis (PEP) in healthcare workers (HCWs) who have been vaccinated with acellular pertussis vaccine and have been exposed to pertussis Secondary Objectives include a comparison of the costs of each PEP strategy and an assessment for risk factors associated with healthcare-associated acquisition of pertussis.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPertussis
CountriesUnited States
CollaboratorsCenters for Disease Control and Prevention
Timeline
N/ACompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartMay 2007
First PostedMay 2007
Primary CompletionDec 2009
TodayJul 2026
First PostedMay 4, 2007
Enrollment StartMay 1, 2007
Primary CompletionDec 1, 2009
TodayJul 2, 2026
Enrollment to primary: 2.6 yearsPosted 19.2 years ago
Interventions
Antibiotic PEPdrug
Azithromycin 1000mg po x 1, then 500mg po Q day for 4 days; TMP-SMX DS one BID for 14 days
Antibiotic PEPdrug
TMP-SMX DS po BID for 14 days