At a glance

ClinicalIndex Comparison Record

N/ACompleted· 18 enrolled

Drug / intervention

Magnetic Resonance Spectroscopy +1 moreprocedure

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00469911

NCT00469911N/ACompleted

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Quantification of Intramyocardial Lipid by Proton Magnetic Resonance Spectroscopy

Washington University School of Medicine·interventional·Posted May 7, 2007·Updated Sep 13, 2018

In Brief

A clinical study evaluating Magnetic Resonance Spectroscopy and Ex vivo heart biopsy for Heart Transplantation. Completed, enrolled 18 participants across 1 site.

Detailed Summary

Accumulation of triglycerides in heart tissue has been associated with changes in left ventricular function which can lead to heart failure. Proton magnetic resonance spectroscopy is currently the only non-invasive in vivo method to measure myocardial triglycerides content. The primary goal of this study was to determine if Magnetic Resonance Spectroscopy could effectively measure myocardial triglyceride content in myocardial heart tissue. Thus, quantitative and reliable techniques to monitor in vivo triglyceride accumulation in the heart are important for disease diagnosis and management. Currently, no such imaging method exists.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsHeart Transplantation

CountriesUnited States

CollaboratorsNational Institutes of Health (NIH), National Center for Research Resources (NCRR)

Timeline

N/ACompletedFinished

20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Enrollment StartAug 2005

First PostedMay 2007

Primary CompletionJun 2009

TodayJul 2026

First PostedMay 7, 2007

Enrollment StartAug 1, 2005

Primary CompletionJun 1, 2009

TodayJul 2, 2026

Enrollment to primary: 3.8 yearsPosted 19.2 years ago

Interventions

Magnetic Resonance Spectroscopyprocedure

Magnetic Resonance Spectroscopy is a noninvasive procedure that provides detailed body images on any plane.

Ex vivo heart biopsyprocedure

Heart transplant patients will have their normal clinical routine heart biopsy