CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 78 enrolled
Drug / intervention
Simvastatin 80 mg/day for 6 weeks +1 moredrug
Likely dose
Simvastatin 80 mg/day for 6 weeksfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00474123
NCT00474123N/ACompleted
CompareCT.gov

Comparison of Antiplatelet and Anti-inflammatory Effects of High Dose Statin Monotherapy Versus Moderate Dose Statin Plus Ezetimibe

University of Sao Paulo·interventional·Posted May 16, 2007·Updated Jul 14, 2010

In Brief

A clinical study evaluating Simvastatin 80 mg/day for 6 weeks and Ezetimibe 10 mg / Simvastatin 20 mg for Stable Angina. Completed, enrolled 78 participants across 1 site.

Detailed Summary

Among patients with stable coronary artery disease (CAD), it is not clear if the pleiotropic effects of cholesterol reduction differ between high-dose simvastatin alone and combined ezetimibe/simvastatin. The investigators sought to compare the anti-inflammatory and anti-platelet effects of ezetimibe 10 mg / simvastatin 20 mg (E10/S20) to simvastatin 80 mg (S80).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStable Angina
CountriesBrazil
Collaborators--

Timeline

N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMay 16, 2007
Enrollment StartJan 1, 2006
Primary CompletionJan 1, 2009
Study CompletionAug 1, 2009
TodayJul 2, 2026
Enrollment to primary: 3 yearsPosted 19.1 years ago

Interventions

Simvastatin 80 mg/day for 6 weeksdrug

Simvastatin 80 mg/day, single dose, for 6 weeks.

Ezetimibe 10 mg / Simvastatin 20 mgdrug

Ezetimibe 10 mg / Simvastatin 20 mg Patients were treated with daily Ezetimibe 10 mg / Simvastatin 20 mg for 6 weeks