CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 289 enrolled
Drug / intervention
metoclopramide 10 mg +3 moredrug
Likely dose
metoclopramide 10 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00475306
NCT00475306Phase 4Completed
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A Randomized, Facorial Design Study to Optimize the Dose of Parenteral Metoclopramide

Montefiore Medical Center·interventional·Posted May 21, 2007·Updated Dec 31, 2012

In Brief

A Phase 4 clinical trial evaluating metoclopramide 10 mg, Diphenhydramine 25 mg, and 2 other interventions for Nausea and Extrapyramidal Symptoms. Completed, enrolled 289 participants across 1 site.

Detailed Summary

Metoclopramide is a dopamine antagonist frequently used for the treatment of nausea, vomiting, and migraine headaches in Emergency Departments. However, little research has focused on the optimal dose of metoclopramide for treatment of nausea in the emergency department. We propose a randomized, double-blind, placebo controlled trial to investigate the optimal dose of metoclopramide for treatment of nausea.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNausea, Extrapyramidal Symptoms
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMay 21, 2007
Enrollment StartMay 1, 2007
Primary CompletionFeb 1, 2008
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 19.1 years ago

Interventions

metoclopramide 10 mgdrug

an anti-emetic medication

Diphenhydramine 25 mgdrug

used for prophylaxis against akathisia

Placebodrug

placebo

Metoclopramide 20 mgdrug

Metoclopramide 20 mg