At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Reduction of Acute Renal Failure Associated With Cardiovascular Surgery: A Randomized Study Comparing Sodium Bicarbonate to Normal Saline
In Brief
A Phase 2 clinical trial evaluating Sodium bicarbonate, Normal saline, and 2 other interventions for Kidney Failure, Acute and Renal Replacement Therapy. Completed, enrolled 123 participants across 1 site.
Detailed Summary
The purpose of this study is to determine if the incidence of acute renal failure (ARF) in high risk patients who undergo coronary artery bypass grafting (CABG) is reduced by treating patients in the perioperative period with intravenous (IV) sodium bicarbonate. Patients will be randomized in a 50:50 allocation to receive either IV sodium bicarbonate or IV normal saline. The volume of fluid given in each arm of the study is equal. All other interventions in those patients will be according to standard cardiothoracic anesthesia protocol at our institution.
Study Details
Timeline
Interventions
IV bicarbonate given with amount based on patient weight
IV Normal saline with volume given determined by patient weight
IV bicarbonate, dosed by weight
Normal saline, with volume given based on patient weight