CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 865 enrolled
Drug / intervention
Intravenous infusion of saline +1 moredrug
Likely dose
Intravenous infusion of saline 1.65 mlfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00489827
NCT00489827Phase 3Completed
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Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease

University Hospital, Linkoeping·interventional·Posted Jun 21, 2007·Updated May 22, 2024

In Brief

A Phase 3 clinical trial evaluating Intravenous infusion of saline and Intravenous glutamate infusion for Coronary Artery Bypass and 3 related conditions. Completed, enrolled 865 participants across 3 sites.

Detailed Summary

The main purpose of this study is to determine whether intravenous glutamate infusion given in association with surgery for unstable coronary artery disease can protect the heart from myocardial injury, postoperative heart failure and death.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCoronary Artery Bypass, Myocardial Ischemia, Myocardial Infarction, Coronary Artery Disease
CountriesSweden
CollaboratorsRegion Örebro County, Blekingesjukhuset, Karlskrona

Timeline

Phase 3CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJun 21, 2007
Enrollment StartOct 1, 2005
Primary CompletionDec 1, 2009
Study CompletionAug 1, 2022
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 19.0 years ago

Interventions

Intravenous infusion of salinedrug

Intravenous infusion of isotonic saline at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.

Intravenous glutamate infusionother

Intravenous infusion of 0.125 M glutamic acid solution at a rate of 1.65 ml/hour and kg body weight beginning with institution of anesthesia and stopping 2 hours after unclamping of aorta in patients operated for unstable coronary artery disease.