At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Patients With Heartburn Associated With Gastroparesis
In Brief
A Phase 4 clinical trial evaluating Immediate-release omeprazole and Delayed-release omeprazole for Gastroparesis and Gastroesophageal Reflux Disease. Completed, enrolled 12 participants across 1 site.
Detailed Summary
The purpose of this study is to compare the blood drug levels of two prescribed medications, immediate-release omeprazole 40 mg powder and delayed-release omeprazole 40 mg capsule to determine which drug is better absorbed in patients with a slow stomach emptying (gastroparesis). Delayed-release omeprazole has a protective coating to prevent the drug omeprazole from being neutralized by stomach acid. Immediate-release omeprazole has sodium bicarbonate (antacid) which neutralizes the stomach acid, eliminating the need for a protective coating. Immediate-release omeprazole suspension may have a more rapid pharmacokinetic profile and greater overall drug absorption in gastroparesis.
Study Details
Timeline
Interventions
Immediate-release omeprazole 40 mg qam for 7 days
Delayed-release omeprazole 40 mg qam for 7 days