At a glance
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Peri-articular Injections Containing a Corticosteroid During Total Knee Arthroplasty
In Brief
A clinical study evaluating methylprednisolone acetate and active comparator for Osteoarthritis and Post-traumatic; Arthrosis. Completed, enrolled 101 participants across 1 site.
Detailed Summary
Prior to surgery, a pharmacist will randomly assign participating patients to one of two groups. One group will get an injection in the knee during surgery that contains medications to limit pain and an antibiotic. A second group will get an injection in the knee during surgery that contains the same pain medications and antibiotic along with a corticosteroid to control inflammation. Corticosteroids are anti-inflammatory medications, not to be confused with muscle-building anabolic steroids you may have heard about in the news. Each patient will have an equal chance of being in either of the two groups. This study will test the safety and efficacy of methylprednisolone acetate in the treatment of pain and inflammation following total knee replacement.
Study Details
Timeline
Interventions
Same medications and doses as the active comparator, but with the addition of 40 mg of methylprednisolone acetate
bupivacaine HCl 80 mg, morphine 4 mg, epinephrine 300 micrograms, clonidine 100 micrograms, cefuroxime 750 mg, and normal saline