CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 20 enrolled
Drug / intervention
tramadol +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00499746
NCT00499746Phase 2Completed
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Medications Development for Drug Abuse Disorders

National Institute on Drug Abuse (NIDA)·interventional·Posted Jul 11, 2007·Updated Oct 17, 2017

In Brief

A Phase 2 clinical trial evaluating tramadol, placebo, and 2 other interventions for Opioid Abuse and 3 related conditions. Completed, enrolled 20 participants across 1 site.

Detailed Summary

This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram. It has effects similar to morphine, and it may also have effects similar to other drugs like stimulants. The doses of tramadol used in this study are higher than those generally used for the treatment of pain. To be in this study a participant must be a user of opioids (drugs like heroin) and stimulants (drugs like cocaine), but cannot be addicted to either. The person must be between 21-55 years old, and generally healthy. Up to 12 people will take part in this study.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOpioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJul 11, 2007
Enrollment StartNov 1, 2007
Primary CompletionApr 1, 2010
Study CompletionAug 1, 2011
TodayJul 2, 2026
Enrollment to primary: 2.4 yearsPosted 19.0 years ago

Interventions

tramadoldrug

oral dose, once per day

placebodrug

oral dose, once per day

Hydromorphonedrug

oral dose, once per day

Methylphenidatedrug

oral dose, once per day