At a glance
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Effect of a 2-day Bed Rest on Metabolic and Cardiovascular Risk Factors in Type 2 Diabetic Patients
In Brief
A clinical study evaluating Study 2 (48 hours of complete bed rest) for Type 2 Diabetes and Insulin Resistance. Completed, enrolled 16 participants across 1 site.
Detailed Summary
The hypothesis of this study is that bed rest in diabetic patients will result in a deterioration of metabolic control (primarily glucose). Specific aims: 1. To determine the change in metabolic control in type 2 diabetic individuals when three days of bed rest is compared to three days of activity; 2. To determine the rate of progression of the deterioration in metabolic control and the magnitude of the decrease; 3. To assess whether the anticipated deterioration of metabolic control has effects on several parameters of glucose metabolism, including hyperglycemia and hypoglycemia; 4. To determine the effects of bed rest on surrogate markers of atherosclerosis, such as plasminogen activator inhibitor 1 (PAI1), C-reactive protein (CRP), and homocysteine. 5. To compare the effects of 48 hours of bed rest on orthostatic responses in type 2 diabetic patients, and healthy non-diabetics. 6. To make recommendations to the diabetic community to prevent metabolic deterioration during a 3 day hospitalization.
Study Details
Timeline
Interventions
Effects of 48 hours of bed rest on insulin resistance in type 2 diabetic subjects.