At a glance
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The Metabolic Effects of Short-term Walnut Consumption in Subjects With the Metabolic Syndrome
In Brief
A clinical study evaluating Walnuts and Control for Metabolic Syndrome and 2 related conditions. Completed, enrolled 40 participants across 1 site.
Detailed Summary
Walnuts include many potentially beneficial micronutrients and phytochemicals, in this study we propose to examine the effects of walnuts independent of macronutrient content. The purpose of this proposal is to study in depth the short-term effects of walnut consumption in men and women with the metabolic syndrome. Study Aim 1: To investigate the effects of walnuts (48gms per day over 3 days) on insulin resistance in subjects with the metabolic syndrome. Study Aim 2: To investigate the effects of 48gms per day of walnuts over 3 days on lipids and inflammatory markers. Study Aim 3: To assess the possible mechanisms of the biological effects of short-term walnut consumption through assessment of adipokines, resting metabolic rate, gene expression in white blood cells and the effect of walnuts when consumed as part of a mixed meal, on glucose excursions, insulin secretion and the excretion of gut peptides and free fatty acids.
Study Details
Timeline
Interventions
48 Grams of Walnuts Daily
Control Diet with No Walnuts