At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Comparison of Desflurane and Propofol Anesthesia for Off-Pump Coronary Artery Bypass Grafting Surgery
In Brief
A Phase 4 clinical trial evaluating Diprivan (propofol), Astra-Zeneca and Suprane (desflurane), Baxter for Coronary Artery Disease. Completed, enrolled 80 participants across 1 site.
Detailed Summary
The purpose of this study is to prove if anesthesia maintained with the inhaled volatile anesthetic desflurane is superior to the intravenously applied propofol anesthesia in off-pump coronary artery bypass grafting (OP-CABG) surgery as measured by following parameters: 1. hemodynamic parameters during and after the operation, 2. pulmonary gas exchange, need for mechanical ventilation and for ICU and intrahospital stay, 3. release of heart muscle injury markers in response to surgery and intraoperative ischaemia, 4. inflammatory response to the operation. We suspect that insufflation anesthesia with desflurane may be superior to intravenous anesthesia with propofol.
Study Details
Timeline
Interventions
continuous intravenous infusion with a dose of 3-5 mg/kg/h
a vapor concentration of 3-7 vol% is maintained with use of vaporizer and under control of arterial blood pressure, heart rate, and BIS index.