At a glance
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Quantification of the Incretin Effect in Healthy Subjects and Patients With Type 2 Diabetes Using Increasing Amounts of Oral Glucose Challenges
In Brief
An observational study evaluating Oral Glucose Tolerance Test, Isoglycemic clamp, and 1 other intervention for Incretin Effect. Completed, enrolled 16 participants across 1 site.
Detailed Summary
Patients with T2DM lac a sufficient incretin response after oral glucose intake. It has only been tested using 50g of glucose. We don't know if patients with T2DM are capable of regulating the incretin effect like healthy people in responds to different amounts of glucose intake. The aim of the present study is to quantify the incretin effect in healthy subjects and in patients with T2DM during increasing amounts of oral glucose challenges. The proposed studies will answer important questions on the mechanisms underlying T2DM and be of importance in relation to future preventive- and treatment strategies.
Study Details
Timeline
Interventions
The test is preformed 3 times with 3 different amounts of glucose (25g, 75g and 125g) deluded in 300ml of water.
I.v. glucose infusion initiating the glucose responds curves from the OGTT
Paracetamol absorption test. Intake of 1,5g of paracetamol followed by measuring the absorption curve