CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 101 enrolled
Drug / intervention
carvedilol phosphate +3 moredrug
Likely dose
carvedilol phosphate 20mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00553969
NCT00553969Phase 2Completed
CompareCT.gov

Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease. DETECT (DEtection and Treatment of Early Cardiovascular Disease Trial)

University of Minnesota·interventional·Posted Nov 6, 2007·Updated Apr 24, 2018

In Brief

A Phase 2 clinical trial evaluating carvedilol phosphate, lisinopril, and 2 other interventions for Pre-hypertension. Completed, enrolled 101 participants across 1 site.

Detailed Summary

This study will examine the individual and combined effects of Coreg CR and lisinopril, on cardiovascular health as measured by Rasmussen Disease Score (RDS) in a blinded, placebo controlled comparison over a 9-month study period. Patients to be randomized will have pre-hypertensive blood pressures that do not require anti-hypertensive therapy and at least one additional cardiovascular risk factor.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPre-hypertension
CountriesUnited States
CollaboratorsGlaxoSmithKline

Timeline

Phase 2CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedNov 6, 2007
Enrollment StartNov 1, 2007
Primary CompletionSep 1, 2010
Study CompletionDec 1, 2010
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 18.7 years ago

Interventions

carvedilol phosphatedrug

Extended release capsules, 20mg once daily for 1 month, 40mg once daily for 8 months

lisinoprildrug

tablets, 10mg once daily for 1 month, 20mg once daily for 8 months

carvedilol phosphate and lisinoprildrug

carvedilol phosphate = extended release capsules, 20mg once daily for 1 month, 40mg once daily for 8 months; lisinopril= tablets, 10mg once daily for 1 month, 20mg once daily for 8 months

placebo and placebodrug

capsule once daily for 9 months; dosage unknown