CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 381 enrolled
Drug / intervention
Sinovial® (syringe containing sodium hyaluronate solution) +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00556608
NCT00556608Phase 4Completed

Efficacy Evaluation of Intra-articular Hyaluronic Acid (Sinovial®) vs Synvisc® in the Treatment of Symptomatic Knee Osteoarthritis. A Double-blind, Controlled, Randomised, Parallel-group Non-inferiority Study

IBSA Institut Biochimique SA·interventional·Posted Nov 12, 2007·Updated Dec 4, 2012

In Brief

A Phase 4 clinical trial evaluating Sinovial® (syringe containing sodium hyaluronate solution) and Synvisc® ( syringe containing Hylan G-F 20 solution) for Osteoarthritis, Knee. Completed, enrolled 381 participants across 20 sites in 6 countries.

Detailed Summary

The purpose of this study is to prove the non-inferiority of the intra-articular injection of hyaluronic acid (Sinovial®) in the symptomatic treatment of knee OA in comparison to Synvisc®.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCzechia, France, Germany, Italy, Slovakia, Switzerland
Collaborators--

Timeline

Phase 4CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedNov 12, 2007
Enrollment StartNov 1, 2007
Primary CompletionJul 1, 2009
Study CompletionMay 1, 2010
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 18.6 years ago

Interventions

Sinovial® (syringe containing sodium hyaluronate solution)device

2 mL 0.8% sodium hyaluronate (16 mg) solution. 3 intra-articular injections once-a-week.

Synvisc® ( syringe containing Hylan G-F 20 solution)device

2 mL 0.8% Hylan G-F 20 (16 mg) solution. 3 intra-articular injections once-a-week.