CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 210 enrolled
Drug / intervention
tiotropium bromide +2 moredrug
Likely dose
tiotropium bromide 18 mcgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00565266
NCT00565266Phase 3Completed
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Asthma Clinical Research Network (ACRN) Trial - Tiotropium Bromide as an Alternative to Increased Inhaled Corticosteroid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (TALC)

Milton S. Hershey Medical Center·interventional·Posted Nov 29, 2007·Updated Jul 2, 2018

In Brief

A Phase 3 clinical trial evaluating tiotropium bromide, salmeterol xinafoate, and 1 other intervention for Asthma. Completed, enrolled 210 participants across 10 sites.

Detailed Summary

Typically, people with asthma are initially prescribed a low dose of inhaled corticosteroid (ICS) medication to control asthma symptoms. If a low dose of ICS is ineffective at controlling symptoms, the addition of a second controller medication is recommended. This study will examine the effectiveness of the medication tiotropium bromide combined with a low dose of ICS at maintaining asthma control in people with moderately severe asthma.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAsthma
CountriesUnited States
CollaboratorsNational Heart, Lung, and Blood Institute (NHLBI)

Timeline

Phase 3CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedNov 29, 2007
Enrollment StartMay 1, 2008
Primary CompletionMay 1, 2010
TodayJul 2, 2026
Enrollment to primary: 2 yearsPosted 18.6 years ago

Interventions

tiotropium bromidedrug

tiotropium bromide inhalation powder 18 mcg once daily

salmeterol xinafoatedrug

salmeterol xinafoate inhalation powder 50 mcg twice daily

beclomethasone dipropionatedrug

beclomethasone dipropionate 80 mcg twice daily (1xICS) or 160 mcg twice daily (2xICS)