At a glance
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Cocaine Withdrawal and Pharmacotherapy Response
In Brief
A clinical study evaluating sugar pill, Carvedilol 25 mg, and 1 other intervention for Cocaine Dependence and Opiate Dependence. Completed, enrolled 106 participants across 1 site.
Detailed Summary
A total of 120 male and female opioid dependent cocaine users will participate in this study. This study will be a 8-week double-blind, placebo controlled study examining the dose-dependent effects of carvedilol (up to 50 mg/day) in methadone stabilized patients. The design will have two phases: 1) a four-week "treatment " phase; and 2) a 4 week " taper and detoxification or transfer" phase. Subjects will be cocaine users who are on stable doses of methadone (60 to 140 mg/day). Carvedilol dose will be increased from 12.5mg/day to the target dose of either 25 or 50 mg/day as tolerated. At the end of the treatment-phase, subjects will undergo detoxification from methadone over a 2 to 4-week period based on an individual's needs, and they will concurrently be tapered off carvedilol.
Study Details
Timeline
Interventions
Subjects randomized to placebo, carvedilol 25mg or 50mg
subjects randomized to placebo, carvedilol 25mg or 50mg
subjects randomized to placebo, carvedilol 25mg or 50mg