At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Apple Flavanols on Risk of Cardiovascular Disease
In Brief
A clinical study evaluating Low PA apple puree, High PA apple puree, and 1 other intervention for Cardiovascular Disease. Completed, enrolled 26 participants across 1 site.
Detailed Summary
A randomised three period cross over trial will be carried out in adults (19-64 years) to assess the acute and chronic effects of a large dose of apple procyanidin (PA) compared with a low dose of apple PA (negative control) and aspirin (positive control), on platelet function and other risk factors of cardiovascular disease. Platelet function will be assessed prior to a run in diet and at the start and end of each intervention. Volunteers will be assigned at random to consume 230grams of low PA apple puree or high PA apple puree or aspirin (75mg) each day for 2 weeks followed by a minimum 14 day wash out. Hypothesis: Consuming apple PA reduces platelet function consistent with reduced risk of cardiovascular disease.
Study Details
Timeline
Interventions
Golden Delicious apple puree 230grams consumed daily for 14 days
High PA apple puree (Mitchalin) consumed daily for 14 days
75mg dispersable aspirin taken daily for 14 days