CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 308 enrolled
Drug / intervention
Furosemide-Q12 hour bolus +3 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00577135
NCT00577135Phase 3Completed
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Diuretic Optimal Strategy Evaluation in Acute Heart Failure (The DOSE-AHF Study)

Duke University·interventional·Posted Dec 19, 2007·Updated Mar 6, 2018

In Brief

A Phase 3 clinical trial evaluating Furosemide-Q12 hour bolus, Furosemide-Continuous Infusion, and 2 other interventions for Heart Failure. Completed, enrolled 308 participants across 9 sites in 2 countries.

Detailed Summary

Heart failure is a disorder in which the heart does not pump blood adequately. This can lead to several serious problems, including reduced blood flow throughout the body, congestion of blood in the veins and lungs, and fluid accumulation in various organs and limbs. Diuretics are often used to address the problem of fluid accumulation, but the optimal dose and the amount of time over which to administer each dose are unclear. This study will compare high and low doses of diuretics administered over longer and shorter periods of time to determine the safest and most effective combination.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHeart Failure
CountriesCanada, United States
CollaboratorsNational Heart, Lung, and Blood Institute (NHLBI)

Timeline

Phase 3CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedDec 19, 2007
Enrollment StartFeb 1, 2008
Primary CompletionJan 1, 2010
Study CompletionFeb 1, 2010
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 18.5 years ago

Interventions

Furosemide-Q12 hour bolusdrug

Q12 hours bolus

Furosemide-Continuous Infusiondrug

Continuous infusion

Furosemide-Low Intensificationdrug

1x oral dose

Furosemide-High Intensificationdrug

2.5x oral dose