At a glance
ClinicalIndex Comparison RecordPhase 2Completed· 93 enrolled
Drug / intervention
CliniMACsdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
CHP 834 Unrelated and Partially Matched Related Donor Peripheral Stem Cell Transportation With the CliniMACs Device for T and B Cell Depletion
In Brief
A Phase 2 clinical trial evaluating CliniMACs for Immunodeficiencies. Completed, enrolled 93 participants across 1 site.
Detailed Summary
This is a pilot study with 2 strata to evaluate engraftment and graft vs. host disease (GVHD) in patients receiving unrelated or partially matched related donor peripheral stem cells using the CliniMACS system to positively deplete T cells to prevent severe GVHD. Feasibility will be tested, focusing on engraftment, treatment-related mortality (with a specific focus on interstitial pneumonitis) and severe GVHD.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsImmunodeficiencies
CountriesUnited States
Collaborators--
Timeline
Phase 2CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartJan 2005
First PostedDec 2007
Primary CompletionJan 2017
Study CompletionDec 2017
TodayJul 2026
First PostedDec 21, 2007
Enrollment StartJan 1, 2005
Primary CompletionJan 15, 2017
Study CompletionDec 30, 2017
TodayJul 2, 2026
Enrollment to primary: 12.0 yearsPosted 18.5 years ago
Interventions
CliniMACsdevice
T and B Cell depletion