At a glance
ClinicalIndex Comparison RecordPhase 3Completed· 80 enrolled
Drug / intervention
inhaled nitric oxide +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effects of Inhaled Nitric Oxide on Ischemia-Reperfusion Injury in Human Liver During Transplantation
In Brief
A Phase 3 clinical trial evaluating inhaled nitric oxide and nitrogen gas for Reperfusion Injury and Liver Injury. Completed, enrolled 80 participants across 2 sites.
Detailed Summary
This blinded, placebo-controlled study will administer inhaled nitric oxide to patients undergoing liver transplantation. The purpose of the study is to test if inhaled nitric oxide prevents liver injury associated with the restoration of blood flow. The premise of the current study is provided by previous studies which document a protective effect of inhaled nitric oxide in this clinical setting.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsReperfusion Injury, Liver Injury
CountriesUnited States
CollaboratorsMallinckrodt, University of Washington
Timeline
Phase 3CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedDec 2007
Enrollment StartApr 2008
Primary CompletionMar 2009
Study CompletionOct 2012
TodayJul 2026
First PostedDec 28, 2007
Enrollment StartApr 1, 2008
Primary CompletionMar 1, 2009
Study CompletionOct 1, 2012
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 18.5 years ago
Interventions
inhaled nitric oxidedrug
inhaled 80ppm for duration of surgery.
nitrogen gasdrug
inhaled