At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluation of Blood as a Submucosal Cushion During Endoscopic Polypectomy and Mucosal Resection
In Brief
A Phase 2 clinical trial evaluating Autologous blood injection, Normal saline, and 1 other intervention for Large Polyps in the Gastrointestinal Tract. Completed, enrolled 18 participants across 1 site.
Detailed Summary
For removal of large flat lesions of the gastro-intestinal tract injection of a solution under the lesion creates a "safety" cushion and protects from damage to the gastrointestinal tract wall. Various solutions are currently used, but some of them are easy to inject but quickly dissipate (normal saline),other solutions are more longer lasting (hydroxypropyl methylcellulose, hyaluronic acid, etc) but are very difficult to inject and can be expensive and not always available. The investigators performed previously animal experiments which demonstrated that blood is easy to inject and creates a protective cushion which lasts longer than other fluids which are currently used for protective cushion creation.
Study Details
Timeline
Interventions
Autologous blood will be drawn from the patient and then reinjected under the lesion to create a safety cushion
Normal saline will be injected under the lesion to create submucosal cushion
Hydroxypropyl methylcellulose (HPMC) will be injected under the lesion to create submucosal cushion