At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions
In Brief
A Phase 4 clinical trial evaluating ketamine and midazolam and etomidate, fentanyl, and lidocaine for Conscious Sedation Failure During Procedure. Completed, enrolled 50 participants across 1 site.
Detailed Summary
There are multiple retrospective studies detailing the use of etomidate in pediatric procedural sedation but few to no prospective clinical trials. None have compared etomidate to ketamine, currently the most commonly used sedative in the emergency department for pediatric procedural sedation. The investigators propose a randomized, controlled trial comparing etomidate versus ketamine for procedural sedation for fracture reduction for children presenting with extremity fracture requiring sedation for reduction. The investigators hypothesize that etomidate in combination with fentanyl will have similar reduction of distress and procedural recall as ketamine in combination with midazolam.
Study Details
Timeline
Interventions
ketamine 1 mg/kg/dose, midazolam 0.05 mg/kg/dose max 2 mg
etomidate 0.2 mg/kg/dose, fentanyl 1 microgram/kg/dose, lidocaine 0.5 mg/kg/dose