At a glance
ClinicalIndex Comparison RecordN/ACompleted· 54 enrolled
Drug / intervention
L-NAME +2 moredrug
Likely dose
L-NAME 4mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
PET Detection of the Effects of Aging on the Human Heart. Aim#1-Impact of Aging on Myocardial Remodeling: Role of Nitric Oxide
In Brief
A clinical study evaluating L-NAME, L-Arginine, and 1 other intervention for Cardiovascular Diseases. Completed, enrolled 54 participants across 1 site.
Detailed Summary
The purpose of this study is to determine, with Positron Emission Tomography (PET), the role of nitric oxide in the age-associated effect on fatty acid and glucose delivery on myocardial substrate metabolism.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCardiovascular Diseases
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA)
Timeline
N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartSep 2005
First PostedJan 2008
Primary CompletionJun 2008
TodayJul 2026
First PostedJan 29, 2008
Enrollment StartSep 1, 2005
Primary CompletionJun 1, 2008
TodayJul 2, 2026
Enrollment to primary: 2.8 yearsPosted 18.4 years ago
Interventions
L-NAMEdrug
nitric oxide synthase inhibitor 4mg/kg infusion over 30-60 minutes prior to PET imaging
L-Argininedrug
aids in nitric oxide production
Phenylephrinedrug
alpha agonist; 10 μg/kg/min infusion during PET study