CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 12 enrolled
Drug / intervention
Na-ASP-2 Skin Test Reagentbiological
Likely dose
Na-ASP-2 Skin Test Reagent 1000 mcgfrom record
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Search/NCT00603889
NCT00603889N/ACompleted
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Development of a Skin Test to Detect Immediate-type Hypersensitivity to the Experimental Na-ASP-2 Hookworm Antigen

Albert B. Sabin Vaccine Institute·interventional·Posted Jan 29, 2008·Updated Feb 23, 2012

In Brief

A clinical study evaluating Na-ASP-2 Skin Test Reagent for Hookworm Infection and Allergy. Completed, enrolled 12 participants across 1 site.

Detailed Summary

Na-ASP-2 is a protein expressed during the larval stage of the N. americanus hookworm life cycle. In a clinical study in previously hookworm-infected adults in Brazil, this protein induced urticarial reactions (rash) in a subset of volunteers. This study will evaluate solutions of varying concentrations of the protein in both a skin prick-puncture and intradermal test that will eventually be used to screen volunteers living in hookworm endemic areas who are being considered as potential participants in vaccine trials, to reduce the potential of inducing allergic reactions in those vaccinated with the Na-ASP-2 Hookworm Vaccine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHookworm Infection, Allergy
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJan 29, 2008
Enrollment StartMar 1, 2008
Primary CompletionMay 1, 2008
TodayJul 2, 2026
Enrollment to primary: 2 monthsPosted 18.4 years ago

Interventions

Na-ASP-2 Skin Test Reagentbiological

Na-ASP-2 Hookworm Skin Test Reagent, 1-1000 mcg/mL solution