CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 31 enrolled
Drug / intervention
Inhaled placebo + oral placebo +8 moredrug
Likely dose
Inhaled alprazolam 0.5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00603980
NCT00603980Phase 1Completed
CompareCT.gov

Abuse Liability Study of Staccato® Alprazolam for Inhalation in Subjects With Histories of Sedative Abuse

Nova Pneuma Inc.·interventional·Posted Jan 29, 2008·Updated Apr 22, 2026

In Brief

A Phase 1 clinical trial evaluating Inhaled placebo + oral placebo, Inhaled alprazolam 0.5 mg, and 7 other interventions for Abuse Liability of Staccato Alprazolam. Completed, enrolled 31 participants across 1 site.

Detailed Summary

Compare the abuse liabilities of Staccato Alprazolam, oral immediate-release alprazolam, and Staccato Placebo.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAbuse Liability of Staccato Alprazolam
CountriesUnited States
Collaborators--

Timeline

Phase 1CompletedFinished
20082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJan 29, 2008
Enrollment StartJan 1, 2008
Primary CompletionJan 1, 2009
TodayJul 2, 2026
Enrollment to primary: 1 yearPosted 18.4 years ago

Interventions

Inhaled placebo + oral placebodrug

Inhaled Staccato placebo + oral placebo

Inhaled alprazolam 0.5 mgdrug

Inhaled Staccato alprazolam 0.5 mg + oral placebo

Inhaled alprazolam 1 mgdrug

Inhaled Staccato alprazolam 1 mg + oral placebo

Inhaled alprazolam 2 mgdrug

Inhaled Staccato alprazolam 2 mg + oral placebo

Oral alprazolam 1 mgdrug

Oral alprazolam 1 mg + Inhaled placebo

Oral alprazolam 2 mgdrug

Oral alprazolam 2 mg + Inhaled placebo

Oral alprazolam 4 mdrug

Oral alprazolam 4 mg + Inhaled placebo

Oral alprazolam 2 mg qualifying sessiondrug

Qualifying session (2 mg oral alprazolam)

Oral placebo qualifying sessiondrug

Qualifying control session (oral placebo)