At a glance

ClinicalIndex Comparison Record

Phase 3Completed· 252 enrolled

Drug / intervention

Dopamine +1 moredrug

Likely dose

Dopamine 20 mcg/kgfrom record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00604019

NCT00604019Phase 3Completed

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Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock

Rush University Medical Center·interventional·Posted Jan 29, 2008·Updated Jan 11, 2023

In Brief

A Phase 3 clinical trial evaluating Dopamine and Norepinephrine for Septic Shock. Completed, enrolled 252 participants across 1 site.

Detailed Summary

We are performing a prospective, randomized, controlled trial of dopamine versus norepinephrine for septic shock. The trial will enroll patients with suspected or documented site of infection and having 2 out of the three SIRS criteria. Patients will also be receiving standard of care, early-goal directed therapy including but not limited to fluid resuscitation, appropriate and early antibiotics, source control and evaluation for drotrecogin alpha where deemed appropriate, while being supported for septic shock.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsSeptic Shock

CountriesUnited States

Collaborators--

Timeline

Phase 3CompletedFinished

2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Enrollment StartMar 2003

First PostedJan 2008

Primary CompletionAug 2009

TodayJul 2026

First PostedJan 29, 2008

Enrollment StartMar 1, 2003

Primary CompletionAug 1, 2009

TodayJul 2, 2026

Enrollment to primary: 6.4 yearsPosted 18.4 years ago

Interventions

Dopaminedrug

Dopamine 5-20 mcg/kg/min to pre-determined max of 20

Norepinephrinedrug

Norepinephrine 5-20 mcg/min, to a pre-determined max of 20