At a glance
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Investigation of Ranibizumab for the Treatment of Persistent Diabetic Neovascularization as Assessed by Super Wide-Field Angiography (Optos)
In Brief
A Phase 2 clinical trial evaluating ranibizumab and Laser photocoagulation for Proliferative Diabetic Retinopathy. Completed, enrolled 9 participants across 1 site.
Detailed Summary
Diabetic neovascularization refers to a type of diabetic retinopathy which is worsening by the abnormal growth of blood vessels in the back of the eye, damaging the retina. The usual treatment is a type of laser, called panretinal photocoagulation. One drawback is that the amount of space within the eye for use of this treatment eventually has its limit, and should not be used too near the part of the retina used for detailed vision (the macula). In similar eye disorders, there are certain injectable medications called anti-VEGF treatments which can slow down or stop this abnormal blood vessel growth. This study sought to compare use of ranibizumab versus standard panretinal photocoagulation in treatment of diabetic neovascularization.
Study Details
Timeline
Interventions
One 0.5 mg intravitreal injection
panretinal photocoagulation (up to 500 300-500 um laser spots)