At a glance
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Oxidative Stress in Sleep Apnea and Cardiac Disease
In Brief
A clinical study evaluating Continuous Positive Airway Pressure (CPAP) and Sham CPAP for Sleep Apnea Syndromes and 2 related conditions. Completed, enrolled 153 participants across 1 site.
Detailed Summary
Sleep-disordered breathing (SDB) is a condition in which a person experiences frequent breathing pauses during sleep, also known as sleep apnea. There is evidence that the recurrent sleep arousal and associated shortage of oxygen in the body may increase risk for cardiovascular disease (CVD). It is believed that treatment with continuous positive airway pressure (CPAP) may reduce certain risk factors for heart disease, including markers of inflammation and oxidative stress. This study will evaluate the effectiveness of CPAP in reducing CVD risk factors in people with SDB.
Study Details
Timeline
Interventions
Participants will use the higher pressure CPAP, as determined by an in-laboratory attended titration study, every night for 12 weeks.
Participants will use the lower pressure CPAP every night for 8 weeks.