At a glance
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Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency
In Brief
A clinical study evaluating GnRHant - Ganirelix acetate, Transdermal estradiol patch, and 1 other intervention for Arterial Stiffening and 2 related conditions. Completed, enrolled 155 participants across 1 site.
Detailed Summary
The purpose of this study is to find out why women's arteries stiffen as they go through menopause, and how this is affected by estrogen loss. We believe that arteries stiffen with the loss of estrogen because of "oxidative stress," the production of molecules that can damage cells and tissues in the body, and because the arteries lose their ability to expand, or dilate.
Study Details
Timeline
Interventions
1 subcutaneous injection at 0.5 mg then daily injections of 0.25 mg for 6 days (total of 7 days of injections); testing will occur on injection day 4 and day 7
0.075mg/d starting on day 4 of the injections following testing time point two; continue for 3 days and retest (day 7)
Starting on day 4 of the injections following testing time point two; continue for 3 days and retest (day 7)