At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Small Changes in Plasma Valproic Acid Concentration on the Photoparoxysmal Response
In Brief
A Phase 4 clinical trial evaluating Valproic Acid and Placebo for Photosensitive Epilepsy. Completed, enrolled 13 participants across 2 sites.
Detailed Summary
We are trying to learn if small changes in the amount of a valproate in the blood (given through an IV) will change the way the brain reacts to flashing lights.
Study Details
Timeline
Interventions
The investigators will utilize intravenous sodium valproate at visit 3. Dosage will be individualized to each patient's body weight, age, and hepatic-enzyme-inducing status. Intravenous VPA dose predictions will be based upon population VPA pharmacokinetic parameters (Dutta 2003).
Each patient will have a placebo-infusion (with 0.9% NS or D5W) of 12-hour duration at visit 2.