CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 180 enrolled
Drug / intervention
Ethanol High Dose, Ethanol Low Dose, and Placebodrug
Likely dose
Ethanol High Dose, Ethanol Low Dose, and Placebo 100mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00612352
NCT00612352N/ACompleted
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Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism

Yale University·interventional·Posted Feb 11, 2008·Updated Oct 26, 2021

In Brief

A clinical study evaluating Ethanol High Dose, Ethanol Low Dose, and Placebo for Alcoholism. Completed, enrolled 180 participants across 1 site.

Detailed Summary

The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism. This study may lead to an enhanced understanding of the underlying neurobiological mechanism in high risk individuals that may lead to the transition from moderate to excessive use of alcohol.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAlcoholism
CountriesUnited States
CollaboratorsVA Connecticut Healthcare System, National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Timeline

N/ACompletedFinished
200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 11, 2008
Enrollment StartMar 1, 2001
Primary CompletionJun 1, 2015
TodayJul 2, 2026
Enrollment to primary: 14.3 yearsPosted 18.4 years ago

Interventions

Ethanol High Dose, Ethanol Low Dose, and Placebodrug

Three test days will involve administration of placebo, ethanol high dose (BrAc=100mg%) or ethanol low dose (BrAc=40mg%)intravenously for approximately 20 minutes, until the target BrAc is achieved. Once BrAc is achieved (40mg% or 100mg%) it will be maintained using a clamp procedure for 60 minutes.